Do You Work With Both Cold Email and Opt-In Marketing Email?

February 12, 2026

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Yes. We work across all email contexts – cold outreach, ecommerce transactional, SaaS mixed streams, lifecycle email, traditional marketing, and API-based transactional systems. The problems are different in shape but similar in root cause. Understanding one context helps you understand all of them because the underlying mechanics are the same.

Here’s why this matters.

The Reputation Bleeding Problem

Most companies don’t realize that sending different types of email from the same domain means they share sender reputation. A complaint spike in your cold outreach damages the reputation of your transactional email. Low engagement on marketing campaigns affects how mailbox providers treat your cold email. Volume surges in one stream can trigger filters that affect another. This isn’t technical – it’s how mailbox providers actually work.

Let me give you a real example. A SaaS company had healthy marketing deliverability – 95% inbox placement, good engagement rates, no complaints to speak of. Then they started a cold outreach program from the same sending domain. The cold email had a 1.5% complaint rate (normal for cold outreach). But within two months, complaints from that stream had degraded the domain reputation enough that their transactional email (critical alerts and password resets) started getting delayed by 2-5 minutes. Their marketing campaigns that used to hit the inbox 95% of the time were now hitting 70%. The company thought they had three separate problems (cold email failing, transactional email slow, marketing email spam). Really, they had one problem: reputation damage from cold outreach affecting the whole domain.

An ecommerce business might have clean transactional email reputation but poor marketing deliverability, and assume they need a completely separate infrastructure or new ESP. Often the problem is different: they’re sending too much volume from the same sending IP, or from an IP that wasn’t warmed properly for the volume they’re sending now. The transactional stream is small and high-engagement, so it’s fine. But the marketing stream is much larger and lower-engagement, and that difference in scale and engagement is dragging down what should be a reputation asset.

Same Diagnostics, Different Applications

We use the same diagnostic framework for every context because the underlying system is the same: sender reputation, authentication, behavior patterns, and mailbox provider response to those patterns.

For a cold email specialist, we assess list quality (are you mailing mostly engaged prospects or are you mailing a lot of inactive addresses that will complain?), sending cadence (are you ramping too fast relative to your domain age?), complaint risk (are you looking at current complaints or modeling future ones?), and the reputation impact of the outreach strategy.

For an ecommerce platform, we assess transaction volume, complaint handling practices, engagement patterns (are you mailing too often to inactive customers?), and the reputation infrastructure needed to handle scale.

For a SaaS company, we assess whether their transactional and marketing streams are properly segmented, whether their volume increases are outpacing their reputation growth, whether their complaint handling processes are catching problem patterns early.

The diagnosis answers the same question in each case: What’s causing the deliverability problem, and what combination of authentication fixes, reputation recovery, behavior changes, and infrastructure adjustments will solve it?

Systemic Problems Cross Streams

We’ve seen problems where it looks like “cold email isn’t working” but the real issue is that the same domain is sending high-volume cold outreach (with normal cold email complaint rates) that’s degrading the overall domain reputation.

That reputation damage then affects transactional email, marketing campaigns, and everything else from that domain. The company thinks they have a cold email problem. Really, they have a segmentation problem – they shouldn’t be sending cold from this domain at all, or they need to warm the domain differently before scaling cold outreach.

We’ve seen cases where “marketing email is going to spam” but the real cause is that transactional email has a complaint problem (maybe they’re sending too many notifications, or retention is bad, or they’re not managing list quality), and that’s damaging the domain reputation for everything else. The company thinks they need to fix their marketing list. Really, they need to fix their transactional complaint rate.

These problems are impossible to solve if you treat each stream independently. You need someone who can see all the streams, understand how they interact, and identify where the actual bottleneck is.

Mixed-Mode Operations Are Complex

Many companies operate in multiple email contexts simultaneously. A B2B software company might send transactional alerts, marketing campaigns, cold sales outreach, onboarding sequences, and lifecycle retention email from overlapping infrastructure. Each context has different standards for what’s acceptable (cold email can have 1-2% complaints, transactional should have <0.1%, marketing should be 0.3-0.5%). They have different engagement expectations. They have different sending patterns. Conflicts between them can mask the real problem.

We work inside that complexity and help you understand what’s actually happening. Sometimes that means recommending proper segmentation onto separate infrastructure (separate IPs, separate domains, or at minimum separate sending addresses). Sometimes it means fixing reputation in one stream, which automatically fixes another. Sometimes it means adjusting sending behavior in a way that solves problems across multiple streams at once.

Understanding Infrastructure Trade-Offs

When you’re running multiple email types, you have infrastructure choices. You can segment onto separate IPs but from the same domain (reputation separate, but brand unified). You can segment onto separate sending domains (reputation completely separate, but multiple brand identities). You can share everything and rely on volume mix to maintain reputation (cheapest, but riskiest). You can use subdomain separation (partially separate reputation, still branded to main domain).

Each choice has different consequences for deliverability, brand perception, and cost. During a diagnostic, we help you understand which choice makes sense for your business.

No Judgment on Intent

We’re not here to evaluate whether your cold outreach is “good” or “bad,” or whether your email practices are ethical. We work within compliance standards (CAN-SPAM, GDPR, etc.) and industry best practices, but we’re focused on helping you achieve your email goals safely and effectively.

If you’re sending cold email, we help you do it in a way that doesn’t destroy your sender reputation and doesn’t invite regulatory problems. If you’re sending marketing email, we help you build and maintain reputation so mail lands in the inbox. If you’re operating multiple streams, we help you structure them so they don’t interfere with each other. If you want to send aggressive volume, we help you warm infrastructure and manage reputation so it’s sustainable.

We’d love to learn more about your business, email deliverability and outreach goals, and see if we might be able to help.

Whether you have questions about what we do, how Protocol works, or you’d just like to pick our brains on some of our best practices, we’d be happy to chat.

Schedule a call with our Revenue Director, Chrisley Ceme.

Talk To Chrisley

Yes. We work across all email contexts – cold outreach, ecommerce transactional, SaaS mixed streams, lifecycle email, traditional marketing, and API-based transactional systems. The problems are different in shape but similar in root cause. Understanding one context helps you understand all of them because the underlying mechanics are the same.

Here’s why this matters.

The Reputation Bleeding Problem

Most companies don’t realize that sending different types of email from the same domain means they share sender reputation. A complaint spike in your cold outreach damages the reputation of your transactional email. Low engagement on marketing campaigns affects how mailbox providers treat your cold email. Volume surges in one stream can trigger filters that affect another. This isn’t technical – it’s how mailbox providers actually work.

Let me give you a real example. A SaaS company had healthy marketing deliverability – 95% inbox placement, good engagement rates, no complaints to speak of. Then they started a cold outreach program from the same sending domain. The cold email had a 1.5% complaint rate (normal for cold outreach). But within two months, complaints from that stream had degraded the domain reputation enough that their transactional email (critical alerts and password resets) started getting delayed by 2-5 minutes. Their marketing campaigns that used to hit the inbox 95% of the time were now hitting 70%. The company thought they had three separate problems (cold email failing, transactional email slow, marketing email spam). Really, they had one problem: reputation damage from cold outreach affecting the whole domain.

An ecommerce business might have clean transactional email reputation but poor marketing deliverability, and assume they need a completely separate infrastructure or new ESP. Often the problem is different: they’re sending too much volume from the same sending IP, or from an IP that wasn’t warmed properly for the volume they’re sending now. The transactional stream is small and high-engagement, so it’s fine. But the marketing stream is much larger and lower-engagement, and that difference in scale and engagement is dragging down what should be a reputation asset.

Same Diagnostics, Different Applications

We use the same diagnostic framework for every context because the underlying system is the same: sender reputation, authentication, behavior patterns, and mailbox provider response to those patterns.

For a cold email specialist, we assess list quality (are you mailing mostly engaged prospects or are you mailing a lot of inactive addresses that will complain?), sending cadence (are you ramping too fast relative to your domain age?), complaint risk (are you looking at current complaints or modeling future ones?), and the reputation impact of the outreach strategy.

For an ecommerce platform, we assess transaction volume, complaint handling practices, engagement patterns (are you mailing too often to inactive customers?), and the reputation infrastructure needed to handle scale.

For a SaaS company, we assess whether their transactional and marketing streams are properly segmented, whether their volume increases are outpacing their reputation growth, whether their complaint handling processes are catching problem patterns early.

The diagnosis answers the same question in each case: What’s causing the deliverability problem, and what combination of authentication fixes, reputation recovery, behavior changes, and infrastructure adjustments will solve it?

Systemic Problems Cross Streams

We’ve seen problems where it looks like “cold email isn’t working” but the real issue is that the same domain is sending high-volume cold outreach (with normal cold email complaint rates) that’s degrading the overall domain reputation.

That reputation damage then affects transactional email, marketing campaigns, and everything else from that domain. The company thinks they have a cold email problem. Really, they have a segmentation problem – they shouldn’t be sending cold from this domain at all, or they need to warm the domain differently before scaling cold outreach.

We’ve seen cases where “marketing email is going to spam” but the real cause is that transactional email has a complaint problem (maybe they’re sending too many notifications, or retention is bad, or they’re not managing list quality), and that’s damaging the domain reputation for everything else. The company thinks they need to fix their marketing list. Really, they need to fix their transactional complaint rate.

These problems are impossible to solve if you treat each stream independently. You need someone who can see all the streams, understand how they interact, and identify where the actual bottleneck is.

Mixed-Mode Operations Are Complex

Many companies operate in multiple email contexts simultaneously. A B2B software company might send transactional alerts, marketing campaigns, cold sales outreach, onboarding sequences, and lifecycle retention email from overlapping infrastructure. Each context has different standards for what’s acceptable (cold email can have 1-2% complaints, transactional should have <0.1%, marketing should be 0.3-0.5%). They have different engagement expectations. They have different sending patterns. Conflicts between them can mask the real problem.

We work inside that complexity and help you understand what’s actually happening. Sometimes that means recommending proper segmentation onto separate infrastructure (separate IPs, separate domains, or at minimum separate sending addresses). Sometimes it means fixing reputation in one stream, which automatically fixes another. Sometimes it means adjusting sending behavior in a way that solves problems across multiple streams at once.

Understanding Infrastructure Trade-Offs

When you’re running multiple email types, you have infrastructure choices. You can segment onto separate IPs but from the same domain (reputation separate, but brand unified). You can segment onto separate sending domains (reputation completely separate, but multiple brand identities). You can share everything and rely on volume mix to maintain reputation (cheapest, but riskiest). You can use subdomain separation (partially separate reputation, still branded to main domain).

Each choice has different consequences for deliverability, brand perception, and cost. During a diagnostic, we help you understand which choice makes sense for your business.

No Judgment on Intent

We’re not here to evaluate whether your cold outreach is “good” or “bad,” or whether your email practices are ethical. We work within compliance standards (CAN-SPAM, GDPR, etc.) and industry best practices, but we’re focused on helping you achieve your email goals safely and effectively.

If you’re sending cold email, we help you do it in a way that doesn’t destroy your sender reputation and doesn’t invite regulatory problems. If you’re sending marketing email, we help you build and maintain reputation so mail lands in the inbox. If you’re operating multiple streams, we help you structure them so they don’t interfere with each other. If you want to send aggressive volume, we help you warm infrastructure and manage reputation so it’s sustainable.

Our Revenue Director, Chrisley Ceme, is leading the Triggered Outbound program.Chrisley’s gone deep on this strategy and can walk you through:

  • How Triggered Outbound fits with your outbound goals
  • What triggers are available (and what’s possible within our platform)
  • Pricing, onboarding, and getting started
Talk To Chrisley

Senders Case Studies

See All Case Studies

Momofuku

Founded by chef David Chang, Momofuku is a renowned culinary brand with a nation-wide presence, including restaurants and an online store with delicious goods. They ran into an issue with their email sending – high bounce rates and blocked sending. With hundreds of thousands of people on their email lists eager to stay informed, and an impeccable reputation to uphold, Momofuku wanted to nip this problem in the bud quickly.

  • Momofuku reached out to Senders to run a diagnostic test on their sending infrastructure and find the root cause
  • Senders deliverability experts discovered an issue with their DMARC, which was preventing emails from being sent, as their WordPress wasn't aligned with their SPF
  • Senders provided the most effective solution helping Momofuku restore safe sending, and suggested next steps to ensure everything keeps running smoothly on their end
  • The client reported that Senders helped identify the problem and got them back on track 

Andrew Yeung

Where many others see a problem, Andrew sees an opportunity. His work may center around product leadership at Google (and previously Meta), but his true calling is all about bringing brilliant change-makers together.

How it started: Andrew hosted small-scale dinners for a handful of people at the peak of the pandemic in NYC, to enable safe connections during the most isolating times. How it’s going: His events now count as many as 2,000 tech leaders each, and he has set up 100+ such parties for more than 15,000 people in the past couple of years. Andrew understands that if two minds are better than one, putting two thousand together, preferably in the same room, can make a profound difference.

Given the impact of his community-building efforts, people want him to be able to reach out – and email is often the best way to do so. So, we helped out a bit.

  • Andrew came across deliverability issues that prompted him to get in touch with Senders and look into the best possible solutions
  • The Senders team made the necessary domain configuration adjustments, with a focus on the domain’s email authentication settings to enhance security and deliverability
  • The SPF record was updated to include “Brevo” (Sendinblue) to strengthen authentication and reduce the chance of landing emails into spam
  • The DMARC policy update enabled better readability of DMARC reports for human analysts, which is essential for preventing email spoofing and phishing
  • Senders fixed the missing DKIM setup with Google, so that it now shows the email hasn’t been tampered with in transit
  • As a result, the client now has better, more stable email deliverability and security

Myrina.ai

Stands out as a trailblazer in empowering women entrepreneurs through technology and a supportive community.

Myrina.ai offers a cutting-edge range of AI-powered SaaS marketing and sales tools that cater specifically to female entrepreneurs and women-led businesses. Myrina.ai enables users to automate marketing and sales, while helping them scale their authentic selves while saving time and boosting conversions. Their Myrina’s Army community fosters a supportive platform that champions female entrepreneurs and their values, empowering them to conquer barriers and achieve their business goals. The company's dedication to providing not only top-notch technological solutions but also a platform for networking and mentorship underscores their commitment to fostering success among women in the entrepreneurial space.

Naturally, they wanted to make sure their email sending infrastructure was set up correctly to protect their reputation and successfully reach their recipients. Our deliverability team worked with the client’s team on:

  • Aligning the client’s three domains with Amazon to make sure they are compatible and optimized in order to integrate with Amazon’s system
  • Setting up a proper DMARC policy to protect their domains against unauthorized use and phishing scams
  • Enhancing email deliverability as well as security, so that each email sent from these domains can be properly authenticated and more likely to land in the right inbox
  • As a result, the client can protect the reputation of their business and domains, while safely sending out their email campaigns

Physician’s Choice

Sometimes the sheer number of options of any product can be daunting – how on earth do you pick the right one? This is especially true with supplements, as we can find them just about anywhere, but we can rarely understand a third of the ingredients listed. Unlike most, Physician’s Choice provides supplements with pure, potent ingredients that work. No fillers or “proprietary” blends with unidentified ingredients. They do the research, so you don’t have to.

  • The client’s team spotted issues with DMARC failures in Google Postmaster
  • The Senders deliverability team worked with the client to update the DMARC configuration to enable report collection
  • The client is now able to obtain detailed reports to diagnose the exact causes of the failures and prevent them in the future with proper DMARC setup